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Inside of a research in breast cancer cells, The mix of lapatinib, a dual HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented both of those HER2 and HER3 phosphorylation induced by INK128 and developed synergistic induction of cell Demise in different HER2-constructive cell traces immune to trastuzumab and lapatinib. In vivo3-O-p-Cou